Larghetti made his professional debut on 15 March 2009, scoring a fifth-round disqualification win over Boris Uhlik.
In his fifteenth fight, on 18 November 2011, Larghetti won his first regional championship—the vacant WBC Silver International cruiserweight title—by stopping Laszlo Hubert in six rounds.
[1] This was improved upon two years later, on 15 June 2013, when Larghetti stopped Vincenzo Rossitto in eight rounds to become the European Union cruiserweight champion.
[3] In 2014, having fought exclusively in Italy, Larghetti received an opportunity to fight for his first world title, against long-reigning WBO cruiserweight champion Marco Huck in Germany.
[4] Huck went on to win a wide unanimous decision, handing Larghetti his first professional loss, but the conclusion of the fight was criticised when Huck appeared to score a last-second knockout in the final round; this was overturned by the referee, who ruled that Larghetti's knockdown had occurred after the bell had sounded.