Mirko Palazzi (born 21 March 1987) is an Italian-Sammarinese footballer who plays as a defender for Tre Penne and the San Marino national team.

At Rimini he also capped for San Marino, a city state bordering Marche and Romagna region, in the last two matches of 2006 FIFA World Cup qualification (UEFA), as well as a game in UEFA Euro 2008 qualifying.

Palazzi then played 2 seasons in Serie D for Verucchio, a local side within the Province of Rimini.

Palazzi played for Sanmarinese amateur club Tre Penne.

Ahead of the 2019/20 season, Palazzi joined Italian club AS San Giovanni Marignanese.