Mission Hill[a] is an American adult animated sitcom created by Bill Oakley and Josh Weinstein for The WB.

Mission Hill was conceived in 1997 by Bill Oakley and Josh Weinstein, former executive producers/showrunners of The Simpsons, with the original artistic designer being Lauren MacMullan.

[7][8] MTV's production of the similarly titled adult animated series Downtown eventually forced a name change.

It featured the voices of Wallace Langham, Scott Menville, Brian Posehn, Vicki Lewis, Nick Jameson, Tom Kenny, Herbert Sigüenza, Jane Wiedlin, Tress MacNeille and Lisa Kushell.

The theme song is a faster, instrumental version of "Italian Leather Sofa" by Cake, who Oakley and Weinstein were fans of.

[9] When the series was first sold to the WB, it was not yet synonymous with teen female-oriented drama programs such as Dawson's Creek, Felicity and Roswell, and its only popular show with that demographic was Buffy, which premiered at the beginning of 1997.

The success of Buffy and similar programs led to The Baltimore Sun labelling it as the "teen girl network" in July 1999, two months before Mission Hill premiered.

[5] On June 30, 2020, Oakley announced plans for a spin-off tentatively titled Gus and Wally, which will center on the middle-aged gay couple who were supporting characters in Mission Hill.

[15] In June 2022, Oakley claimed that they were still in the process of pitching the project, and that if this version was picked up, then it would continue under the Mission Hill moniker, rather than being titled Gus and Wally.

Set in the world of teens and 20-somethings, this series follows hip 24-year-old Andy French, whose sheltered suburban teenage brother Kevin moves in with him and his roommates in a big-city loft.

However, several of the animatics—including a completed video animatic and synchronized audio read-through of the episode "Pretty in Pink (Crap Gets in Your Eyes)"—have been released through various internet outlets.

Eventually, an argument breaks out between Andy, Posey and Kevin about whether or not they should go to an Indian casino, the boys' grandmother's house or a large field of sunflowers.

Boston, MA has a neighborhood called Mission Hill in the Roxbury section of the city which bears many similarities to its fictional counterpart.