The Missisquoi North River flows through the municipalities of Eastman, Stukely-Sud, Saint-Étienne-de-Bolton, Bolton-Est, Mansonville and Potton, in the Memphrémagog Regional County Municipality, in the administrative region of Estrie, in Quebec, in Canada.

Two streams (coming from the north and the northwest) flow into Parker Lake (altitude: 246 metres (807 ft)).

Then the current descends on 1.2 kilometres (0.75 mi) to the north shore of Lac d'Argent (length: 1.7 kilometres (1.1 mi); altitude: 246 metres (807 ft)) that the current crosses south over its full length; this lake flows into the North Missisquoi river by a small bay south of the lake.

From this bay, the North Missisquoi River flows for 7.1 kilometres (4.4 mi) south to the northeast shore of Trousers Lake (altitude: 239 metres (784 ft)) that the current crosses towards the southwest on 1.5 kilometres (0.93 mi).

The toponym "Rivière Missisquoi Nord" was formalized on December 5, 1968, at the Commission de toponymie du Québec.