It provides general medical services to residents of central and southern Mississauga as well as regional stroke, cardiac, and neurological care.

[2] The name was reverted to Mississauga Hospital following Trillium Health Centre's merger with Credit Valley Hospital on December 1, 2011, to form Trillium Health Partners.

[3] In 2022, Trillium received a $105 million donation from the Peter Gilgan Foundation, for this hospital and Queensway Health Centre.

[4] The hospital's annual Diwali dinner has become known as one of Mississauga's premier social events.

[9] The Trillium Hospital Bus Terminal is a MiWay bus terminal located on the northern side of the Mississauga Hospital site, facing the Queensway.