Mississippi's 3rd congressional district (MS-3) covers central portions of state and stretches from the Louisiana border in the west to the Alabama border in the east.

Large cities in the district include Meridian, Starkville, and Pearl.

The district includes Mississippi State University in Starkville.

Oktibbeha County communities in the 3rd include Starkville, Mississippi State, and Longview; Jones County communities include Sandersville, Sharon, and part of Laurel; and Madison County communities include Madison, Ridgeland, most of Gluckstadt, and parts of Canton and Flora.

The Hinds County portion of the district takes in eastern Jackson.