Subsequent erosion caused a deep trough that was flooded by the Gulf of Mexico and eventually filled with sediment from the Mississippi River.
The northern end of the embayment appears as an anomalous break in regional geologic structure with Paleozoic sedimentary rocks both to the east in Kentucky and Tennessee and to the west in Missouri and Arkansas.
The more recent opening of the Atlantic Ocean and Gulf of Mexico during late Paleozoic to early Mesozoic break-up of Pangea no doubt affected and may have partially re-activated the old rift.
The uplifted land quickly eroded and, as North America moved away from the hot spot and as the hotspot's activity declined, the crust beneath the embayment region cooled, contracted and subsided to a depth of 2.6 km, forming a trough that was flooded by the Gulf of Mexico.
[1] Evidence for this explanation is found in the presence of the seismic zones centered on New Madrid, Missouri, and Charleston, South Carolina, each the source of devastating earthquakes in the 19th century, and in diamond-bearing kimberlite pipes in Arkansas, which are products of volcanism.