[3][4] MS 182 begins at a junction with US 82 northwest of Kilmichael in Montgomery County, heading southeast on a two-lane undivided road through woodedland.

The highway intersects the southern terminus of MS 745 near the center of town and continues past more residences on South Rutherford Drive.

[4][5] MS 182 begins at an intersection with US 82 west of Eupora in Webster County, heading northeast as a two-lane undivided road.

[4][6] MS 182 begins at an intersection with US 82 west of Starkville in Oktibbeha County, heading southeast as a two-lane undivided road.

At this interchange, the highway becomes a four-lane road called Dr. Martin Luther King, Jr. Drive West and passes commercial development before it narrows back to two lanes and runs through wooded areas with homes and businesses.

The highway comes to an interchange with the US 82/MS 12/MS 25 freeway in Clayton Village, after which it narrows back into a two-lane undivided road that runs through rural land with some commercial development.

The highway leaves the downtown area and continues past businesses and some homes, becoming a five-lane road with a center left-turn lane and crossing a Kansas City Southern Railway line.

MS 69/MS 182 curves northeast, narrowing to three lanes, before turning back east and crossing an Alabama and Gulf Coast Railway line.

The roadway continues through commercial areas and passes to the south of a park, becoming a four-lane undivided road, before crossing Luxapallila Creek.

Farther east, the highway leaves Columbus and becomes a two-lane undivided, unnamed road that runs through woodland with some fields and development.