The Crawford section, designated in 2007, runs south to north from US 45 Alt.

[1] In Lowndes County, MS 245 starts at its intersection with US 45 Alt., and it begins traveling northwestwards.

MS 245 intersects multiple streets as it turns north towards US 45 Alt.. North of Long Street, the road begins to bend northeastwards, and it soon ends at US 45 Alt.

[3] MS 245 turns north at CRD 149 and enters Okolona at Filgo Road.

[9] Inside the city, the road is known as Church Street, and it enters travels through the residential areas around it.

[9] The road turns northeastwards at that point, and it begins traveling through farmland.

[7] Past Chiwapa Creek, MS 245 enters Shannon,[10] and it is known as Romie Hill Avenue.

The road intersects the entrance of Shannon Elementary School at Mobley Street.

This was planned as part of the 1987 Four-Lane Highway Program, and the section cost $18.7 million.