It runs from the community of Arkabutla in Tate County, north across Arkabutla Dam, to the Tennessee border in DeSoto County, where it continues as Tennessee State Route 175 (SR 175 / Weaver Road).

It travels northward, concurrent with MS 304 Scenic, through farmland to leave the community and wind its way through hilly woodlands for a few miles to pass along the shores of Sunfish Bay (part of Arkabutla Lake).

The highway now passes along the western side of the Arkabutla Dam, where it crosses a bridge over the Coldwater River into DeSoto County.

[1][3] MS 301/MS 304 Scenic now leaves the Dam area as they turn left onto Pratt Road and head west.

They then cross Cub Lake Bayou before making a right turn and heading north again.