MS 304 begins at a trumpet interchange with US 61 east of Tunica Resorts in the northern reaches of the Mississippi Delta region.

I-69/MS 304 crosses another rail line and passes over US 51 with no access just west of the state highway's terminus at I-55 on the northern end of Hernando, where I-69 joins I-55 heading north toward Memphis.

The highways meet at a full cloverleaf interchange and then MS 304 runs east concurrent with Interstate 269 to the Tennessee state line.

MS 304 Scenic crosses an extremely swampy area, which is an extension of the northern part of Arkabutla Lake, before traveling through farmland for several miles to enter the Hernando city limits.

MS 304 Scenic leaves downtown along E Commerce Street and passes through a major business district for several blocks before coming to an end at another interchange with I-55 (exit 280).