The entire length of MS 355 is a rural, two-lane, state highway.

[1][3] The road heads northwest, then north intersecting minor county roads and crossing Mill Creek as it passes through mostly agricultural fields.

At the Pontotoc-Union county line, state maintenance and signage for MS 355 begins.

The highway generally continues northwest through woods and farm fields.

It later curves to the north passing through the community of Etta before ending at MS 30.