[3] Continuing through rural Noxubee County, the route turns northeast at Stevenson Road.

At the Alabama–Mississippi state line, MS 388 ends and SR 86 continues east to Pickensville.

[12][13] The route was widened and built up from Brooksville to Bigbee Valley in 1986, to improve access to a Weyerhaeuser paper mill.

Improvements to the route east of Bigbee Valley were not completed, as it was owned by Noxubee County, and MDOT could not take ownership until the road was upgraded.

[14] In March 1988, a Weyerhaeuser pulp mill was approved for construction, and Noxubee County received federal funding to rebuild the route.