Mississippi Highway 385 (MS 385) is an 11.150-mile-long (17.944 km) unsigned state highway located entirely within Chickasaw County in the U.S. State of Mississippi.

The entire length of MS 385 is maintained by Chickasaw County.

The road enters the Tombigbee National Forest, and it turns northeast past CR 163.

North of CR 213, the road turns west and enters Van Vleet.

At CR 164, the road turns north and enters the center of the community.