MS 430 begins in the Mississippi Delta region in Leflore County in the city of Greenwood at an intersection with U.S. Route 82 (US 82)/MS 7 just southeast of downtown.

It heads southeast as a four-lane undivided highway through neighborhoods before leaving Greenwood and narrowing to two-lanes.

State maintenance of the highway temporarily ends at the county line as MS 430 travels southeast through farmland.

The highway travels through a mix of farmland and wooded areas for about nine miles (14 km) to pass through Blackhawk, where it has an intersection with MS 17.

They head west to have an interchange with Interstate 55 (I-55) at its exit 174 before MS 430 splits off along Mulberry Street and passes straight through downtown.