The section from US 61 to the Warren–Issaquena county line was designated "William W. "Bill" Ramsey Memorial Highway" in 2009.

[1] The highway starts at a T-intersection with US 61,[4] a part of the Great River Road,[5] north of Redwood.

[4] MS 465 continues to journey westward in Issaquena County, following the Yazoo River while surrounded by multiple smaller ponds.

The highway continues westward, crossing another bridge and passing nearby a cemetery.

About four miles (6.4 km) later, the route turns northeastward, no longer concurrent with the levee.

The highway becomes surrounded by forests until it intersects Mannie Road, where it begins traveling northward into farmland.

[6] Past the village of New Fitler, the road turns northward, adjacent to the Steele Bayou.

[8][9] A year later, a section of the highway became paved in northwest Warren County,[9][10] and its southern terminus was realigned to north of Vicksburg by 1958.

[10][11] The terminus continued to shift north to parallel the Yazoo River the next two years, ending near Redwood.