Mississippi Highway 463 (MS 463) is a north–south state highway in Madison County, Mississippi, connecting U.S. Route 51 (US 51) in Madison to MS 22 east of Flora.

It intersects Interstate 55 (I-55) at the state's only single-point urban interchange.

[2] MS 463 starts at the intersection of US 51 and Hoy Road in Madison, and travels westward from the center of the town.

The road, known as Madison Parkway, crosses over a railroad and intersects Main Street.

The route then travels northwestwards on Main Street and meets I-55 at a single-point urban interchange.