The route starts at MS 28 near Georgetown, and it travels north through western Simpson County.

[1] The route starts at MS 28 at a three-way junction east of Georgetown, and travels north through a forested area.

[4] Proceeding through a mix of farmland and forests,[6] the road crosses Mountain Creek south of McGee Lane and enters the town of Florence at Old US 49.

[4] MS 469, known as South Church Street inside the town,[7] intersects multiple driveways and an entrance to a park.

[6] The route turns east at West Main Street near the center of Florence and intersects US 49 after crossing the Illinois Central Railroad.

[7] The route continues through suburban parts of the town, with Florence High School located at Williams Road.