Interstate 20 (I-20) is a major thoroughfare through the central region of the US state of Mississippi.

Spanning 154.5 miles (248.6 km), it connects Jackson and I-55 with Vicksburg and the Mississippi River in the west and Meridian and I-59 in the east.

Interstate 20 enters in west from Tallulah, Louisiana into Vicksburg, Mississippi.

It then enters the Jackson area with Clinton, Mississippi and makes an interchange with U.S. Route 80 towards Clinton-Raymond Road.

This interchange splits making I-55 go north towards Downtown Jackson and Memphis, Tennessee.