The majority of the route is a dirt road that runs through De Soto National Forest.

The two-lane state-maintained[2] roadway heads north as George Boutwell Road.

It heads past some houses and open fields and makes a sharp curve to the east before resuming a northeasterly course.

Through the Wayne County portion, MS 536 remains on an easterly course through the forest, though some open fields and homes appear along the road.

Its length on Camp 8 Road is short, totaling about 400 feet (120 m), as it comes to an end at an intersection with MS 63, about four miles (6.4 km) southwest of Clara and about eleven miles (18 km) southwest of Waynesboro.