It heads north as a four-lane divided highway to immediately leave Pascagoula and enter neighboring Moss Point, where it passes through some neighborhoods to have an intersection with Grierson Street (unsigned MS 618) and cross over the Escatawpa River.

MS 57/MS 63 travel straight through downtown along Main Street (passing by the Greene County Courthouse) before the two highways split on the western side of town, with MS 63 heading northwest to pass by the South Mississippi Correctional Institution before cutting in-and-out of the De Soto National Forest for the next several miles.

The highway travels through the community of Sand Hill, where it has an intersection and short concurrency with MS 42, before crossing into Wayne County.

The highway passes through neighborhoods along Turner Street before entering downtown and coming to an end at an intersection with MS 184 (Azalea Drive).

[2] Mississippi Highway 63 provides part of a four-lane corridor connecting Moss Point and the Gulf Coast with US 45 north to Meridian.

Costing $13.6 million, the second phase widening MS 611 to five lanes from Old Mobile Highway to the Chevron refinery in Pascagoula, commenced in March 2014.