Mississippi Highway 584 (MS 584) is a 25.1-mile-long (40.4 km) state highway in Amite and Pike counties of southern Mississippi, United States.

It heads south through neighborhoods along Gillsburg Road before turning east along Osyka Road to leave Liberty and continue southeast through a mix of farmland and wooded areas for the next several miles, where it crosses a bridge over the East Fork Amite River.

The highway then passes through Gillsburg, where it has an intersection with MS 568 and crosses a bridge over the Tickfaw River.

It now crosses into Pike County and has an interchange with Interstate 55 (I-55) at its exit 1 shortly before entering Osyka.

MS 584 enters the town along Liberty Street and passes southeast through neighborhoods before coming to an end at an intersection with U.S. Route 51 (US 51), just northwest of downtown.