Mississippi Highway 859 (MS 859) is a highway in Central Mississippi in Gluckstadt.

The highway's southern terminus is at Church Road/Old Jackson Road in Gluckstadt.

It travels north to its northern terminus at MS 857 in Gluckstadt.

[1][2] The highway carried 5,600 vehicles on average in 2023.

[3] The entire route is in Gluckstadt, Madison County.