Route 10 is a highway in Clay, Ray, and Carroll counties in western Missouri, United States.

At North Brighton, it turned south and onto Winn Road, crossing what is now Interstate 35 (I-35).

It then followed the current route of Route 210 and Armour Road into North Kansas City, turning southward at Burlington Road/Route 9 and crossing the Missouri River terminating at US 24/US 40 in downtown Kansas City.

A five mile business route of MO 10 exists in Richmond.

Media related to Missouri Route 10 at Wikimedia Commons