Route 157 is a short highway in Adair County, Missouri.

It runs less than five miles (8 km) and there are no towns on the highway.

Route 157 begins at the marina on Forrest Lake in Thousand Hills State Park in Adair County, heading north as a two-lane undivided road.

The road curves northwest and heads through forested areas of the state park.

The route continues north and leaves the state park, passing through more forests with some homes.