The eastern terminus is at Route 142 and the road runs straight west for 6 miles (10 km).

Route 158 begins at an intersection with US 67/US 160 (Future I-57) in Butler County, where the road continues west as part of US 160.

From the western terminus, the route heads east as a two-lane, undivided road, passing through a mix of farms and woods with some homes.

Route 158 reaches the community of Harviell, where it passes to the south residences and crosses Union Pacific's Hoxie Subdivision.

Past Harviell, the road runs through farmland and intersects Route BB.