The highway begins at Route 79 in Winfield, MO, where it travels due west towards Troy and Hawk Point, where it turns south and meets Interstate 70 in Warrenton.

The two highways share a concurrency through the Missouri River bottomlands for approximately 4 miles to near Dutzow.

The highway still continues south across the Missouri River into Washington, where it intersects Route 100.

Route 47 runs concurrent with U.S. 50 very shortly before returning south towards St. Clair.

The highway now runs east with that route for about 8 miles, until returning south.