The next year, the original portion from Rocheport to Fayette became part of Route 240.

In 1953/1954, the route extended north to Kirksville, its current terminus.

It then eventually reaches Callao, Missouri and has an interchange with U.S. Route 36 It then heads east and parallels US 36 like a frontage road very shortly before turning south again.

It then continues east on a concurrency with U.S. Route 24 before heading south again in an intersection to the west of Huntsville, Missouri.

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