Route 99 is a short highway in southern Missouri.

Its northern terminus is at U.S. Route 60 just north of Birch Tree in Shannon County; its southern terminus is at U.S. Route 160 south of Thomasville in Oregon County 18.3 miles (29.5 km) to the SSE.

It crosses the Eleven Point River at Thomasville.

[1] Just south of Thomasville Route 99 provides access to the west end of the Eleven Point Wild and Scenic River portion of the Mark Twain National Forest.

This Missouri road-related article is a stub.