Construction is complete to divide the highway through Wayne, Madison and Butler Counties, including bypasses around Greenville and Cherokee Pass.

About 25 miles (40 km) north of Bonne Terre, US 67 crosses Interstate 55 and enters Festus and Crystal City and picks up US 61.

This becomes known as Truman Boulevard in Festus and Crystal City, Highway 61-67 from Herculaneum to Imperial, and Jeffco Boulevard from Arnold until it exits Jefferson County and enters St. Louis County, where it becomes Lemay Ferry Road.

Lindbergh, named for aviator Charles Lindbergh, continues north through Frontenac, Ladue, Creve Coeur, Maryland Heights, Bridgeton, Hazelwood and Florissant until it reaches Lewis & Clark Boulevard (Route 367).

Between Fort Bellefontaine, Missouri (near Lewis Bridge) and south of St. Louis, US 67 followed two different routes.

US 67 originally followed Lewis and Clark Boulevard, Florissant Avenue, 7th Street, and Broadway south through St. Louis.

The portion of US 67 between the Arkansas state line and Poplar Bluff is slated to be upgraded into an extension of Interstate 57.

[5] A future segment that’s funded for construction extends from County Road 352 to near Neelyville.