The Missouri Western Griffons football program represents Missouri Western State University in college football and competes in the Division II level (D-II) of the National Collegiate Athletics Association (NCAA).

In 1989, Missouri Western became a member of the Missouri Intercollegiate Athletic Association, which was renamed the Mid-America Intercollegiate Athletics Association (MIAA), and has remained in the league.

Missouri Western's football program dates back to 1970.

Under Jerry Partridge the Griffons have appeared in the Division II playoffs in 2006, 2010, 2011, and 2012.

Official record (including any NCAA imposed vacates and forfeits) against all current MIAA opponents as of the end of the 2015 season: The Griffons have played their home games at Spratt Stadium since 1979.