The team competes in the NCAA Division II and are members of the Mid-America Intercollegiate Athletics Association.

The team plays its home games at the 7,000 seat Fred G. Hughes Stadium in Joplin, Missouri.

Atiba Bradley was named the 14th head football coach in the history of Missouri Southern on February 5, 2021.

[3] Missouri Southern has made one appearance in the NCAA Division II playoffs, with a combined record of 0-1.

Official record (including any NCAA imposed vacates and forfeits) against all current MIAA opponents as of the end of the 2015 season: The Lions has retired only one number.