Misty Lee was born in Mount Clemens, Michigan, and spent most of her childhood in Detroit, which she credits as inspiration for her unique sense of humor and interest in magic.

In addition to magic, Lee is a prolific voice actor, appearing in award-winning video games such as The Last of Us, BioShock Infinite, Grand Theft Auto V, Disney Infinity, the Fire Emblem series, God of War Ragnarök and more.

At San Diego Comic-Con, Lee designed and taught custom effects to celebrity host and presenters for the "Magic of Comics" themed awards show.

[clarification needed][1] Under the training of "Truth Wizard" J.J. Newberry, and alongside agents from the CIA, ATF, and Scotland Yard, Lee mastered the art of cognitive interview techniques, giving her the nickname of "Human Lie Detector".

[1] Lee is married to animation producer and comic book author Paul Dini,[6] with whom she lives in Los Angeles.