[3][4] Mitha Ram Hostel shares a historical connection with D. J. Sindh Government Science College, which was established through the efforts of Indian lawyer, Dayaram Gidumal, in the late 1880s.

[5] Funded by both the Bombay and Karachi governments and private contributions, the college was completed in 1887 and named after Diaram Jethmal, whose family made a significant donation.

[5][3] Notably, the Mitha Ram Hostel played a role in the 1940s independence movement, hosting meetings for activists such as Sobho Gianchandani and Hashu Kevalramani.

[5] In 1992, the hostel was occupied by the Pakistan Rangers and later received the approval by the Chief Minister of Sindh, legitimizing a practice that had occurred without formal agreement for decades.

[5] Initially, the Rangers were stationed at the hostel to maintain order and address escalating incidents of targeted killings and kidnappings in Karachi.