I had to toss aside all my plans to 'save the world' because the ability to make specific DNA molecules for molecular genetic experiments was just too enticing.
[1] Kuroda's work with Yanofsky involved collaboration with Iwona Stroynowski to reveal how a riboswitch mechanism called bacterial attenuation regulates operons for amino acid biosynthesis.
Her citation by the National Academy of Sciences upon her election said, "Her lab identified the MSL ribonucleoprotein complex, and discovered that it assembles and spreads from sites of non-coding roX RNA synthesis to regulate genes specifically on the fruit fly male X chromosome.
Furthermore, they dissected the sex-specific regulation of this process, and the molecular mechanism by which the MSL complex influences transcriptional elongation.
Kuroda's laboratory has shown that BRD4-NUT regulator leads to cancer via causing histone modification changes that produce a cascade of remodeling in which domains are opened to allow inappropriate expression of genes by transcription of their RNA.