After the Conquest, ranchos and haciendas were established in the area, as well as a textile factory which is today forms part of the Mexico City campus of the Universidad Panamericana.
In the late 19th century, wealthy people from Mexico City began establishing summer residences here and in nearby towns such as Tacubaya, San Ángel and Coyoacán.
In 1928 the Municipality of Mixcoac was absorbed into Mexico City proper, becoming part of a new Departamento Central within the Mexican Federal District.
Colegio La Salle Simón Bolívar, another private school, has two campuses in Mixcoac.
[5] Notable residents of Mixcoac have included poets Octavio Paz and Hart Crane, chemist Luis E. Miramontes co-inventor of the progestin norethisterone used in one of the first three oral contraceptives, Mexican president Valentín Gómez Farías, director José Solé, and authors José Joaquín Fernández de Lizardi, whose house is used for classrooms of the Universidad Panamericana and Katherine Anne Porter, the American story writer and novelist, who later translated one of Lizardi's works.