An extension of Line 12 from Mixcoac to Observatorio is under construction, projected to be finished by 2020.

By that time, Mixcoac will no longer work as the western terminus of Line 12.

[7] The station runs deep under Avenida Revolución, a main thoroughfare in Mexico City.

[8] There are two main entrances to the station: one in the west sidewalk of the aforementioned avenue and the other in a small plaza between Avenida Revolución, Avenida Patriotismo, Eje 7 Sur Extremadura and Calle Empresa.

The station pictogram depicts a snake because the Nahuatl name Mixcoac means "Nest of Cloud Serpents".