[citation needed] However, studies revealed the existence of a few cases of WAIHA that may also carry cold agglutinin antibodies that are active at the environment where the temperatures is generally equal to or warmer than 30 °C (86 °F).
Such coexistence suggests a diagnosis of the mixed (warm- and cold-antibody) autoimmune hemolytic anemia abbreviated as MAIHA.
[4][better source needed] Mixed warm and cold AIHA runs a chronic course with severe intermittent exacerbations, such as serious anemia, and is treated by blood transfusion.
Successful therapeutic options for the treatment of hemolysis associated with mixed AIHA are limited but increasing.
First, patients with w-AIHA can produce low-titer, low-thermal amplitude CA of no clinical significance.