Pure red cell aplasia (PRCA) or erythroblastopenia refers to a type of aplastic anemia affecting the precursors to red blood cells but usually not to white blood cells.

In PRCA, the bone marrow ceases to produce red blood cells.

[1] Signs and symptoms may include: Causes of PRCA include: PRCA is considered an autoimmune disease as it will respond to immunosuppressant treatment such as cyclosporin in many patients,[9] though this approach is not without risk.

[10] It has also been shown to respond to treatments with rituximab and tacrolimus.

[citation needed] For cases related to B19 parvovirus, administration of commercial immunoglobulin can treat or cure parvovirus by replacing neutralizing antibodies.