The story focuses on the eponymous protagonist, a Japanese high-school girl who finds herself pulled into various worlds populated by women who consider her appealing.

While the concept of Miyuki-chan in Wonderland was initially imagined as the first chapter by writer Ohkawa, the team continued with it for the enjoyment it provided.

Miyuki-chan in Wonderland was developed by Clamp—the all-female manga artist team consisting of Satsuki Igarashi, Mokona, Tsubaki Nekoi, and Nanase Ohkawa.

[6] In retrospective, the team felt that the manga acted as a showcase for Mokona's "sexy, female character designs", writing: "It was fun, but a little hentai.

[11] Directed by Seiko Sayama and Mamoru Hamazu, the original video animation (OVA) adaptation of the first two chapters of Miyuki-chan in Wonderland was released by Sony Music Entertainment on June 21, 1995.

[15] Patrick King of Animefringe wrote that the illustrations contributed the most appeal to the plotless manga, with the inclusion of a bonus section and colored OVA concept-art pages praised as well.

Anime News Network's Christopher Macdonald recommended it as nonsensical entertainment, describing it as Clamp's tribute to Alice in Wonderland and its sequel Through the Looking Glass (1871).

[14] Another reviewer for Sequential Tart expressed her lukewarm feelings towards the anime, and wrote that it might appeal to fans of Clamp or art films.

[22] While praising the visuals and audio as helping to create a surreal atmosphere, Raphael See of THEM Anime Reviews, in contrast, wrote that the effect was ruined by the sexual nature of the plot; he recommended Dreams (1990) or Robot Carnival (1987) instead.