It was founded on the lands of the Palestinian Arab village of Rub al-Nasra, which were purchased from the Sursock family, a major absentee landowner of Lebanese origin.

During the Mandate era, Mizra hosted the Palmach headquarters, until it was discovered by the British authorities in Operation Agatha of 1946.

The Aliyah from the Commonwealth of Independent States in the 1990s brought Mizra competitors, and it eventually sold 75 percent of the plant to Tiv Ta'am, an Israeli supermarket chain that sells pork.

[4] In 2007, Russian-Israeli billionaire Arcadi Gaydamak announced his plan to purchase Tiv Ta'am and turn it kosher, saying he would make Mizra supply chicken instead of pork.

It also has a hotel and a room letting branch, for students of the nearby Max Stern Academic College of Emek Yezreel.