Tadakiyo and his father were placed under house arrest and the karō of the domain, Mizuno Motonobu, was executed for treason.

In 1869, he was released from house arrest, and in 1870 was appointed imperial governor of Asahiyama in Omi Province.

With the abolition of the han system in 1871, he relocated to Tokyo and enrolled in the Keio Gijuku university.

Mizuno Tadahiro spent 3000 ryō annually from his own fortune to assist ex-samurai of the domain to become farmers.

He died in 1905 without a male heir and his title went to his younger brother, Mizuno Tadazane.