The Saionji survived by the fluid loyalties and fierce resistance, but were eventually overcome by Chōsokabe Motochika, who was in turn overthrown by the forces of Toyotomi Hideyoshi.

When ordered to send troops to the invasion of Korea in 1592, he cut down large trees in shrines and temples throughout his domain to construct ships.

Tomita's wife was the daughter of Ukita Tadaie, and was a famous as a female warrior who had fought against the Mōri army in the Battle of Sekigahara.

Hidemune was the illegitimate eldest son of Date Masamune who had been raised by Toyotomi Hideyoshi, but who sided loyally with the Tokugawa clan at the Siege of Osaka.

[1] Munetoshi's tenure lasted for 36 years, and became a model for later generations; however, he had to contend with droughts, tight finances, floods, large fires, and boundary disputes with the Tosa and Iyo-Yoshida domains.

During this period, droughts, famines, and floods continued, leading to a variety of reforms, including the issuance of paper currency, relief for victims, tree planting, civil engineering projects as emergency employment measures for refugees, and frugality ordinances, but he died suddenly at the age of 31 in May 1735.

In the midst of this, Munetoki died and was succeeded by Date Munenaga who continued his father's reforms centering on the appointment of capable samurai, frugality and expenditure restraint, expansion of revenue through the cultivation of commercial crops and sericulture, and relief for disaster victims.

In 1812, a revolt called the "Hagimori Incident" occurred due to a conflict of opinions among senior vassals over financial reconstruction.

Munenari returned to the forefront after the assassination of Ii Naosuke in 1860, had an audience with Emperor Kōmei and played an important role as a "go between" between the shogunate and the imperial court.

Under the Meiji government, Munenari served as Foreign Secretary, and in April 1871 was appointed ambassador plenipotentiary to conclude the Sino-Japanese Friendship and Trade Treaty.

This was a higher title than the Sendai branch of the clan, but Uwajima played only a minor role in the Meiji government as it had not participated in Boshin War and few of its retainers left the domain for Tokyo.