Mkhombo Nature Reserve is a protected area in Mpumalanga, South Africa.

It is a large, 11,223 ha reserve which conserves an easterly Kalahari thornveld environment around the shores of Mkhombo Dam.

[1] The reserve has typical highland grassland with a network of wetlands and rocky outcrops.

Among the species native to the reserve are the reed cormorant, African yellow-billed hornbill, African grey hornbill, white-breasted cormorant, little swift, hamerkop, red-winged starling, pectoral sandpiper, grey plover, barred wren-warbler, and yellow wagtail.

This Africa protected areas related article is a stub.