Neighboring municipalities are Cumpas in the north, Huásabas, Granados and Divisaderos in the east, Tepache, San Pedro de la Cueva Villa Pesqueira, and Baviácora in the west.

San Miguel Arcángel de Oposura, a large burnt brick church with vaulted ceiling, side bays, and an octagonal chapel with a wooden roof, was built by unidentified maestros brought to the site at great expense by Father Daniel Janusque sometime before his death in 1724.

The region is located in the river basin of the Río Moctezuma between two extensions of the Sierra Madre Occidental mountains.

Corn and beans are raised for subsistence while grasses (sorghum, alfalfa, ryegrass) are grown for cattle fodder.

The former gold-mine La Bambolla is located near Moctezuma, one of the most famous geological deposits of elementary tellurium and its minerals.