[1] The municipal seat of Opodepe is connected to Mex 15 by a road that was gravel in 2005.

The settlement of Querobabi, located near Federal Highway 15 (four-lane toll), has seen an increase in population from 900 in 1980 to 3,900 in 2005 while the municipal seat, located in the hill lands has seen a decrease from over 1,000 to its present population of less than 500.

The name of Opodepe comes from the Opata language, from the roots "opo", which means iron wood, "det" flat, and "pa" place, "in the plain of the ironwood".

The land is divided between hills and flatland and the main settlement lies at an elevation of 596 meters.

Agriculture is used as a support for the cattle industry, with the cultivation of rye grass, barley, sorghum, and alfalfa.