In Latin manuscripts from 1125 and 1156 you can read Murzeke and Murceke, in 1171 Morzeka, in 1225 Morsca, in 1259 and 1261 Morseke, in 1330 Mourseka.

Reformation brought a lot of mayhem: half the parish got burned down and ravaged and even the church didn't escape this.

In 1584 after a siege that lasted for 20 days Moerzeke and Dendermonde were liberated from the Protestants by the Spanish troops.

In 1590 a priest from Hulst (the Netherlands) came to Moerzeke together with some seventy families from Verrebroek and Kieldrecht to bring the population to a normal level again.

Moerzeke holds the burial chapel and associated museum of Father Edward Poppe, who was beatified by Pope John Paul II in 1999.