Mohammad Reza Khanzadeh (Persian: محمدرضا خانزاده; born 11 May 1991) is an Iranian professional footballer who plays as a defender.

[3] After playing good games for his side, fans called him Persepolis' Raphaël Varane.

Khanzadeh returned to Persepolis before the start of 2014–15 season after spending six months at Zob Ahan.

[5] On 28 April 2015, the Iranian Football Disciplinary Committee banned Khanzadeh from competing in any competitive matches in Iran for nine months, but he was allowed to continue to train with Persepolis.

He was called to the Iran U23 team for AFC U-22 Asian Cup qualification by coach Alireza Mansourian.