[1] Al-Sistani primarily runs his father's office and oversees the financial and administrative work.
He conducted his jurisprudence studies under the leading jurist of his time, Sayyid Abu al-Qasim al-Khoei in September, 1979.
He attended the principles of jurisprudence classes of his father, Sayyid Ali al-Sistani, in March, 1991.
The office of his father, the Grand Ayatollah, (of which Mohammed-Ridha is the head) has openly criticised foreign meddling in Iraqi affairs, stating: "No person or group, no side with a particular view, no regional or international actor may seize the will of the Iraqi people and impose its will on them."
[5][6] He played a major role in ending the 2022 Baghdad clashes by calling Muqtada al-Sadr by phone and conveying a message to him from his father Ali al-Sistani, which stated that Sadr was responsible for any bloodshed and urged him to call on his group to end the violence.