Moira also appeared in the game Mercenaries: Playground of Destruction, as the voice of the news reporter Adriana Livingston.

She also voiced Daniella in the video game Haunting Ground, as well as Susie Smythe and Mei Ling on two episodes of What's New, Scooby-Doo?.

Quirk has additionally voiced several minor characters on popular animated series, such as Codename: Kids Next Door and Johnny Bravo.

She has voiced the character Karliah in the role-playing video game The Elder Scrolls V: Skyrim, as well as Elara Dorne in Bioware's MMORPG, Star Wars: The Old Republic, Elhaym "Elly" van Houten in Xenogears, and Dr. Moira Vahlen in XCOM: Enemy Unknown and its expansion, Enemy Within.

She also voiced Phyla-Vell on The Avengers: Earth's Mightiest Heroes and Hannahr in DreamWorks Dragons: Rescue Riders.